RNAi and Cold Sores
RNA interference (or “RNAi”) is a mechanism where fragments of double-stranded RNA interfere with the expression of a particular gene. RNAi is receiving a lot of attention. One reason for this it that it has potential potent antivirus actions, but as you’ll hear in the podcast, there are problems with delivery at the present time.
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Links:
- Silencing Virus Infection. Derek M Dykxhoorn and Judy Lieberman. PLoS Med. 2006 July; 3(7): e242
- Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Gupta A, et al. Nature. 2006 442: 82-85
- Wikipedia – siRNA
- Virus Immunopathology
- Herpes simplex
[...] The Nobel Prize in Physiology or Medicine goes to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference – gene silencing by double-stranded RNA, which, as regular podcast listeners will know, is a very important! Explore posts in the same categories: Science, Medicine [...]
[...] have moved one step closer. When you put this work together with another recent paper showing that RNAi can suppress prion protein polymerization and significantly prolong the survival of [...]
[...] Following the initial infection, herpesvirus latency occurs within neurons or lymphocytes depending on the virus involved. Establishment and maintenance of latency is complex and not completely understood. During latent infection only a very restricted set of virus genes are expressed and the virus does not actively replicate itself. This state can be maintained for a very long time indeed, often for many decades. At some point, the virus is woken from its slumber, often by a physiological change in the host, or …. [...]
Love your blog, will definitely come back…The amount of stimulation that people with ALZHEIMERS DISEASE can tolerate may be in sharp contrast with their past ability. It may be difficult for others to realize just how little stimulation it takes for someone with ALZHEIMERS DISEASE to become mentally tired.
[...] RNAi and Cold Sores [...]
[...] RNAi and Cold Sores [...]
[...] Comments A cream that could stop genital herpes? « MicrobiologyBytes on RNAi and Cold SoresGreg S on What the heck do you microbiologists do all day long?Adenoviruses « [...]