MicrobiologyBytes

2 Comments

• Amiya Sarkar says:

  December 18, 2007 at 6:33 pm

  Too much of a good thing can be really bad then. An eye opening hypothesis.
• colleen says:

  December 23, 2007 at 10:38 pm

  HYPOTHESIS OF AUTO-IMMUNE DISEASE FROM A COMMON PERSPECTIVE :

  NOT A DOCTOR…..NOT MEDICAL ADVICE….

  Adding two nutrient inhibiting acids to about 90% of the processed food and then consuming them in excess, causes a clog in the filter between the blood that carries the nutrients and the cells that have to have the nutrients to survive. The clog results in “cell starvation”. As the cells begin to die the internal negative feedback systems which are the “internal specialist” are activated. The “internal specialist” respond immediately to the deficient nutrients which register as a stressor, but the continuing accumulation from continued consumption of the acids only enhance the clog more. So as the accumulation of the acids continue to be enhanced so does the internal specialist correction attempts. When the clog, which is serving as a nutrient blockage, cannot be removed the conditions in the internal environment are reset. As the conditions move farther and farther away from a normal balance ,“homeostasis”, then problems began to manifest from the long-term adjustments. And problems from the long-term reset adjustments cause symptoms that alert the doctors. The doctors perceive the reset adjustments as abnormalties, and make a diagnose of Auto-immune disease. And so the doctors begin to try to bring the adjustments back to normal, which means suppressing the internal specialist attempt to correct a precise problem. And so lo and behold no “cures”.
  I have written up this hypothesis and I know it is very long but please take the time to read it because I feel this is the root cause of the auto-immune disease epidemic and could annihilate auto-immune diseases altogether.. I believe the excessive consumption of nutrient inhibitors such as oxalic and phytic acids have created the insoluble salt blockage in the interstitial fluid that is causing a malfunction in the delivery system of nutrients to the cells. This is creating the cell starvation that is activating the internal negative feedback system responses that are perceived by the medical community as abnormalities, and thus labeled auto-immune diseases.. And though I am not learned in the chemical aspects of the internal workings of the body I feel a cure will be quite simply undoing the acid blockage so the nutrients can be restored naturally to the cells and the internal systems can settle back down.. I am not a doctor this is just a common person’s perspective. I will only cover a few of the branches of disruptions in depth here, for times sake.

  Thank you for your time..
  Hypothesis :

  Substances with nutrient inhibitors are only suppose to be consumed in moderation, because they cause a nutrient deficiencies in the cells, if consumed in excess.
  So I ask why wouldn’t saturating the food-chain with an ingredient with known nutrient inhibitors, also cause a nutrient deficiency in the cells?
  I believe it would.
  Therefore there may be other ingredients in the food -chain that contain nutrient inhibitors but for the purpose of this hypothesis I will refer to soy because it contains the nutrient inhibitors Oxalic and Phytic acids, and it is an ingredient that is added way in excess to approximately 90% of the food chain. Plus it is also added to the livestock feed which would be altering the animals’ own nutrients and this I believe, has a connection to Mad Cow disease…
  The excessive consumption of oxalic and phytic acids would be creating excessive insoluble calcium salts. These insoluble calcium salts would enter into the (interstitial fluid), the internal environment outside the cells. The cells are unable to utilize the insoluble salts and so the salts become trapped in the interstitial fluid creating a saturation. This saturation leads to the disruption that is causing the malfunction in the nutrient delivery pathway to the cells. Even if the blood has an ample supply of calcium, the interstitial fluid begins to register internally that there is an excess of calcium, but the cells are triggering a starvation of calcium .. The internal systems quickly detect the disruption in the nutrients and triggers “Fight or Flight” responses. The low blood pressure negative feedback system, the 1st stage of shock (compensated shock response) and the 1st stages of the stress response (fight or flight) are all activated.
  As the interstitial fluids become saturated with the insoluble calcium salts this inhibits the (PTH) parathyroid hormone and this is the beginning disruption of Auto-immune disease. As the parathyroid hormone becomes inhibited this disables the PTH/Calcitonin negative feedback system that regulates the calcium/phosphate homeostasis balance. So the phosphates are no longer being triggered for excretion and the calcium is no longer triggered for absorption. So a calcium ion deficiency occurs and the phosphates become excessive. The excessive phosphates causes precipitation of calcium /phosphate salts in bones, soft tissues, joints and arteries.. And as the depositing of these mineral salts in the bones become excessive this causes the bones to become saturated with calcium salts, thus leading to a perpetual disruption in the output of PTH. The inhibited PTH means the Vit. D is not activated, and so the intestine is inhibited from absorbing calcium. And thus the beginning malfunction in the pathway of the nutrient delivery system which triggers the activation of the internal systems that over time branches out into all the auto-immune disease symptoms.
  It would be horrendous if this was the case , but it sure looks like it to me and I am 110% sure that it is.. In my opinion “ AUTO-IMMUNE DISEASE IS ONLY THE LONG-TERM ADJUSTMENTS THE BODY’S INTERNAL SYSTEMS’ ARE MAKING IN RESPONSE TO AN INABLILITY TO DELIVER THE NUTRIENTS TO THE CELLS”, and this could be proven quite simply by a complete and very thorough nutrient test of the cells. A simple blood test would be of little use in determining if the cells are deficient, because the blood would contain the nutrients but the cells cannot utilize them. I have an auto-immune disease and the partial cells test that is available on the market confirm my theory, that my cells are missing very crucial nutrients, and I have connected the deficient nutrients to disruptions being created by the two acids.
  I know that a nutrient disruption would seem too simple, but growing up on a farm I saw cows that happened to consume prussic acid from stressed Johnson grass, they would suffocated and be dead in just a very short time (cyanide aka prussic poisoning.) . The effect by which death was achieved was suffocation by interference with the internal utilization of oxygen by tissues, which translates into the disruption in the cellular metabolism. Oxalic and phytic acid toxicity happens to create a similar disruption in the cellular metabolism, although the extended prolonged time it takes for the accumulation to occur, causes the symptoms to be much slower at manifesting themselves. There happens to be a known treatment for the cyanide poisoning that when administered goes in the blood and reacts with the cyanide forming a relatively inactive compound that is slowly degraded and detoxified by the body. And scurvy and the deaths it caused on the pilgrims journey and cured by something as simple as the Vit. C in lime, comes to mind . And the disease pellagra can be caused by the excessive consumption of corn and cured by bringing vitamins back into the diet. So it is documented in history that lack of nutrients can have a deadly affect It would be dreadful but glorious if the cure for auto-immune disease were so simple. And I believe it will be after the acid disruption has been removed.

  BRANCHES OF DISRUPTION:

  THE NUTRITIONAL PATHWAY BLOCKAGE: If the oxalic and phytic acid salts and complexes are considered ANTIGENS, that are not part of a host tissue cell . Which I feel they qualify as this because they cannot get into the cells. If this is the case they activate the immune complex reactions involved in hypersensitivity. When certain ratios of antigen (the acid complexes) to antibody occur, the complexes are small and escape from phagocytes. The complexes become trapped (clogged) in the basement membrane (filter) under the endothelium of blood vessels, and this activates the complement, and causes an inflammation. (causing conditions such as Bright’s disease-glomerulonephritis, systemic lupus erythematosus (SLE),and rheumatoid arthritis (RA)..And as this basement membrane becomes clogged the exchange by diffusion of nutrients and removal of waste materials between the epithelium and the connective tissue is disrupted… So the functions of the epithelia is disrupted which include protection, filtration, lubrication, secretion, digestion, absorption, transportation, excretion, sensory reception and reproduction… And since the endothelium lines the heart, blood vessels, and lymphatic vessels and forms the walls of capillaries this could account for their inflammations and disruptions ..Blockage in the glandular epithelium would disrupt the secreting portion of the glands, such as the thyroid and the sweat glands…A blockage would also pose a disruption in the sense organs for smell, hearing , vision and touch..

  THE DISRUPTION OF THE THYMUS IN THE IMMUNE RESPONSE: The perception that the Thymus is over -active in auto-immune disease can be explained as follows. The Stress Response to the cell starvation activates the cortisol in excess, which suppresses the IL-1. So the IL-1 is not present to activate the resting inactive helper T cells. This disrupts the Major histocompatibility complex antigens (MHC) process. The MHC-II appears only on T cells that have been activated and on the cells of the Thymus. The T cells’ immune response is disabled because they remain inactive, so the sole responsibility of the immune response is falling on the shoulders of the Thymus. So the Thymus cells are increasing to compensate for the lost activated T cell response, and this internal adjustment comes across as an abnormality. When a peptide fragment from a self-protein is associated with an MHC antigen on the surface of a cell, T cells ignore it.(689 br)
  LOSS OF IMMUNOLOGICAL TOLERANCE LEADS TO AUTOIMMUNE DISEASE:(698 br). After the T cell has gone through the weeding out process in the thymus and been found to be a positive selection it can emerge from the thymus as an immunocompetence T cell. Even after the T cell emerges from the thymus it is possible for it to become anergic if there is no costimulator. B cell from the bone marrow in like manner can become anergic (inactivated ) if the costimulator is not present. This is a process that in most probability would happen with the excess cortisol from the stress response, that would inhibit the production of the IL-1 disrupting the T cell stimulation that in turn would be the costimulator of the B cells.

  RESULTS OF ACTIVATION OF THE STRESS RESPONSE: When a stressor such as deficient nutrients is long-term, the stress triggers a wide-ranging set of bodily changes called the stress response or general adaptation syndrome (GAS). This resets the levels of controlled conditions which allows, for instance, the blood pressure and blood glucose levels to raise above normal. The first pathway is the fight or flight alarm reaction. This stage increase circulation, promotes catabolism for ATP production and decreases nonessential activities such as digestive, urinary, and reproductive activites. But the 2nd stage response the Resistance Reaction which is initiated by hormones: corticotropin releasing hormone (CRH), growth horone releasing hormone (GHRH) and thyrotrophic releasing hormone (TRH)…The CRH stimulates the increase secretion of ACTH and ACTH stimulates the increased secretion of Cortisol.

  Cortisol: (over long term secretion would become excessive causing excesses and thus disruptions the following process)…
  #stimulates gluconeogenesis…(in my opinion enhances blood levels of glucose)
  #enhances protein catabolism…
  #makes blood vessels more sensitive to constriction stimuli…
  #reduces inflammation…( in my opinion helps conceals the cell destruction)
  #discourages formation of new connective tissue…(my opinion would contribute to bone diseases)
  #suppresses production of IL-1…
  The IL-1 turns on the immune system in response to stress. And in the negative feedback system cortisol suppresses this response which keep the immune response in check once it has accomplished its goal. The immune response negative feedback system is disrupted due to the fact the body cannot be brought back into homeostasis removing the stressor. So the immune response is slowed during prolonged resistance stage. (the immune system disruption in Aids, I feel)

  TRH increases secretion of TSH thyroid-stimulating hormone:
  TSH :
  #causes increased secretion of T3 and T4..
  #T3 and T4 stimulate production of ATP from glucose…

  GHRH causes the increased secretion of human growth hormone (hGH) ..
  hGH :
  #stimulates the catabolism of triglycerides ..(triggered at all times)
  # the conversion of glycogen to glucose glycogenolysis (would create a deficiency in glycogen)..
  #TSH and hGH increase catabolism supplying additional ATP for metabolically active cells (cellular metabolism disruption would disrupt the production of the ATP, so trigger would be activated at all times)..

  During the resistance stage blood chemistry should return to nearly normal. And the cells should use the glucose at the same rate it enters the bloodstream. (but in my opinion the cellular metabolism disruption that inhibits the production of ATP, stops the success that would allow the resistance stage to shut off)… So the body would go into exhaustion . Exhaustion happens because chronic and sever stressors deplete the hormonal and other mechanisms of the resistance reaction and lead eventually to failure of mechanisms essential to homeostasis. Problems such as diseases arise when the stress response is activated for too long a period of time.

  HEART DISEASE:

  HEART DISEASE: In my opinion high blood pressure is not the original problem, that is only the internal adjustment. I believe it starts out as a nutrient disruption that the body perceives to be a low blood pressure problem and high blood pressure is the negative feedback systems’ adjustments in an attempt to correct the low blood pressure caused by the oxalic and phytic acid toxicity . This can be confirmed I feel if you compare the low BP negative feedback system’s adjustments with the treatments the medical establishment administers for high blood pressure, they look to be much the same to me. So this tells me the doctors are only treating the internal systems adjustments not the root cause of the problem.

  A lack of nutrients in the cells result in “cell starvation”. so the body perceives the inadequate blood as a low blood supply due to the missing nutrients. Also when the muscle contraction has deficient Ca2+ ions, the heart muscle pump contraction is insufficient and this insufficient pumping in the heart causes low blood pressure which allow the blood to slow down and substances begin to stick to the wall. As cell starvation aka “inadequate blood supply” and decreased blood pressure are detected the body’s internal systems instantly instigate powerful responses. To begin with the body perceives that it is going into shock because the cardiovascular system cannot deliver enough nutrients to meet the metabolic needs of the cells and the internal systems activate the negative feedback system that elevate blood pressure during the compensated non progressive stage of hypovolemic shock , so the “ low blood pressure’s negative feedback system” which is the hormonal regulation of blood pressure is activated ..
  At this time sensors are triggered to cause:
  #increased Renin…
  #increased Angiotensin I…
  #increased activity of (ACE) angiotenesis converting enzyme…
  #increased Angiotensin II…
  #raised blood pressure…
  #potent vasoconstriction…
  #raised total systemic resistance (SR)…
  #increased Aldosterone…
  #increased sodium ion (Na+)…
  #increased water reabsorption…
  #increased total blood volume…
  #increased Epinephrine and Norepinephrine…
  #increased cardiac output…
  #increased rate and force of contractions…
  #vasoconstriciton of arterioles and veins in the skin and in the abdominal organs…
  #vasodilation of arterioles in cardiac and skeletal muscle..
  #increased (ADH) Antidiuretic hormone …
  #inhibited (ANP) Atrial natriuretic peptide…(locked in a fight or flight response with Aldosterone)
  #inhibited Pth’s influence on decreasing and increasing blood pressure…
  #inhibited Calcitriol influence on increasing blood pressure..
  #increased hypoxia….
  #increased dilated arterioles and relaxed precapillary sphincters in response to deficient O2…

  The O2 would be getting low because Oxalic and Phytic and excessive phosphates create insoluble iron complexes, which would lead to an oxygen deficiency… And combine this with the fact that nutritional immunity has activated the inhibiting of iron and zinc and other nutrients in the inflammatory response.
  This leads to a CELLULAR RESPIRATION ELECTRON TRANSPORT CHAIN DISRUPTION: There is not sufficient Oxygen in the cellular electron transport chain to receive the hydrogens passed down the chain , so the last cytochrome in the chain is stuck with the hydrogen. The preceding carrier molecule then has no acceptor to which to give its hydrogen electrons, and the entire system becomes blocked all the way back to NAD and no further ATPs can be produced by way of the electron transport system. This branches into a cellular metabolism disruption causing deficient ATPs, and excessive hydrogen creating acidosis disrupting the pH…
  If the internal balance can be returned to normal then the body goes back into homeostasis and everything settles down and the disease subsides but due to the continued exposure to the two acids homeostasis can not be obtained. So when homeostasis cannot be achieved the stress response’s general adaptation syndrome phase (GAS) is activated and the controlled conditions in the body are reset. At this point blood pressure and levels of blood glucose can rise above normal levels. As the acid disruption continues creating more sever cell starvation and ion imbalances then more powerful responses are activated, so the 2nd stages of the stress response and the 2nd stage of the shock response and the inflammation response and the pulmonary and the systemic circulation make auto regulation responses, and the neg. feedback regulation of erythropoiesis (red blood cell formation) are all activated as the O2, Ca2+ , iron and other nutrients availability decline. At these stages problems began to manifest themselves and this is the point at which I believe the doctors become alerted. At this time they run their test and find the adjustments made by the internal systems and perceive them to be abnormal, and label this auto-immune disease. The doctors then begin giving medications that would be antagonistic to the “internal specialist” systems’ correction attempts. As I said, to collaborate this assumption all a person needs to do is compare the abnormalities the medical establishment are treating for high blood pressure and heart disease with the negative feedback adjustments for Low Blood Pressure , they seem to be pretty much one and the same. So the “internal specialist” are striving to meet a precise goal of correcting a nutritional deficiency, while the outside specialist are working on an obscure problem with an “unknown cause”. The “internal specialist” God created are extremely precise systems skilled in accuracy and they deserve the utmost respect, they are not just haphazard irrational systems with no rhyme or reason that can be dismissed as irreverent… If the establishment continues to think in this manner and over look the knowledge contained in these specialized internal systems, then it is a sure-fire bet we will continue to lose in the battle against auto-immune disease. Instead of declaring something an unknown cause and unknown cure, it would be much better to get to the root of the problem and then start working from there. If it happens to be something as simple as a man-made disruption in the delivery of nutrients to the cells, then so be it. God made the universe and he has the understanding and knowledge about what makes it tick, unfortunately man does not .
  The Symptoms of Shock portray a slow decline created by deficient nutrients, in my opinion:
  1st stage: vasoconstriction of skin, sympathetic stimulation , increased levels of epinephrine, generalized vasodilation, reduced cardiac output, cerebral ischemia , reduced urine formation due to hypotension , increased levels of aldosterone and ADH, thirst due to loss of extracellular fluid, Acidosis caused by buildup of lactic acid, impaired circulation to the digestive system…
  2nd stage: depressed cardiac activity, increased permeability of capillaries, blood volume decreases, intensified hypoxia, blood velocity slows, cellular destruction, heart pumps less effectively, lysosomes rupture, depressed mitochondrial activity, diminished active transport, and decreased metabolism, acidosis caused by metabolic dysfunction, excess lactic acid, depressed central nervous system caused by the acidosis,
  3rd stage: rapid deterioration of the cardiovascular system, as ATPs reserves are depleted in the heart and liver and the heart deteriorates till it can no longer pump blood and death takes place…

  DIABETES:

  Diabetes: I believe diabetes does not start out as a high blood glucose problem, I believe that is only the internal adjustment. I believe it is a disruption in the metabolism of (ATPs) cellular energy that the internal systems perceive to be a low glucose problem. The internal systems are triggered that not enough ATPs are available so they assume the glucose used to make the ATPs is low, so this triggers the release of all glucose to the blood to serve as fuel to make the ATPs. But glucose is not the problem it is the acids disrupting the cellular metabolism process. So when homeostasis still cannot be achieved the body perceives that there is a glucose scarcity, and secretes human growth hormone (hGH). hGH functions to decrease glucose up take, and retard glucose use for ATP production by most body cells, in order to spare glucose for neurons’ use. Add this to the fact that human growth hormone is also activated in the 2nd stage of the stress response, and glucose becomes excessive. This persistent high blood glucose concentration stimulates the pancreas to continually secrete insulin. Such excessive stimulation, if it lasts for weeks or months may cause “beta-cell burnout”. “Beta-cell burnout” means the capacity of the pancreatic beta cells to synthesize and secrete insulin is greatly decreased. Thus, in time, excess secretion of hGH may cause diabetes mellitus (lack of insulin activity).
  The excessive glucose that cannot be utilize eventually exceeds the proteins’ ability to transport , other words exceeds its transport maximum ™ . When the transport ability is exceeded then the glucose spills over into the urine keeping water with it causing larger than normal urine volumes. Thus the would account for the excessive urine volumes in diabetics. The cell starvation would not allow the “I’m satisfied” (satiety center) trigger to be stimulated so the diabetic would feel hungry all the time as well as people with eating disorders.. (This disruption could well be the answer to the obesity epidemic going on). The metabolism of cellular energy (ATP) is the function by which metabolic water is produced. Lack of metabolic water leads to dehydration and dehydration triggers the thirst sensation. In the presence of excessive glucose the cells that line the blood vessels shrink and pull apart to open up gaps, which increases permeability of the filtration membrane in the kidney (endothelial-capsular membrane). Increased permeability of he endothelial-capsular membrane permits proteins to escape from blood into urine.. This is called proteinuria or the Nephrotic syndrome. This disruption results in the loss of albumin which decreases the ability for small particles to be suspended in the blood ( blood colloid osmotic pressure: colloid is a factor in thyroid hormone storage). Proteinuria results in edema, high blood levels of cholesterol, phospholipids, and triglycerides.. So I ask why couldn’t diabetes be a nutritional deficiency?

  BONE DISEASES: OSTEOPOROSIS, ARTHRITIS:
  BONE DISEASES: Imbalances between bone formation and bone reabsorption underlie nearly every disease that influences the adult skeleton.. bone disorders are caused by an imbalance in the osteoclast and the osteoblast. An insufficient secretion of PTH results in inactivity of the osteoclasts. And Calcitonin works antagonistically to the PTH and inhibits osteoclast activity and promotes osteoblast activity.
  SO COULD BONE DISEASES SUCH AS OSTEOPOROSIS, ARTHRITIS, ETC. BE SIMPLY A NUTRIENT DISRUPTION THAT INHIBITS (or nullified) THE PARATHRYROID HORMONE? Most common skeletal disorders are excessive destruction and inhibited formation. I feel because of the PTH disruption, what is happening is the newly formed bone is already in a weakened state due to a loss of too much calcium and the Vit. D deficiency , would be creating bones in an already partially destructed state. And since the old bone is not being destroyed to be replaced by new bone then the old bone is just deteriorating from old age.. Plus oxygen deficient lysosomes become fragile and rupture releasing destructive enzymes and disrupt their ability to carry off debris and that can cause arthritic conditions. Plus excess glucose can form irreversible cross links in adjacent proteins causing stiffening and loss of elasticity..

  THE CRIPPLED IMMUNE RESPONSE IN THE PROCESS OF REMOVAL OF THE EXOGENOUS ANTIGENS, AKA OXALIC AND PHYTIC TOXINS IN THE FLUID OUTSIDE THE CELLS : The excessive long term activation of the stress response releasing cortisol and suppressing the production of IL-1 completely disrupts the T and B cell immune responses. The activation of the T cells is inhibited because IL-1 is the costimulator. The B cell are only antigen-presenting cells, so they can only prepare the exogenous antigens for removal from the fluid. . If the IL-1 is not present to activate the helper T cell then the helper T cells cannot be stimulated to start releasing IL-2. IL-2 is he stimulator of cell division , so at this point the IL-2 positive feedback system is disrupted. IL-2 is needed for virtually all immune responses. IL-2 is the prime substances that triggers and enhances activation and proliferation of T cells, B cells, and natural killer cells.. IL-1 is also necessary to activate the helper T cells to stimulate the secretion of IL-4, gamma-interferon, and transforming growth factor beta (TGF-B)…IL-2 is the stimulator of cell division.. IL-2 binds to IL-2 receptors on neighboring helper T, cytotoxic T, or B cells and if they have already bound an antigen , it serves as a costimulator to activate them.
  The cytotoxic T cells : Must have the IL-2 or other cytokines produced by helper T cells to be able to lyse cells.
  The B cells can secrete the antibodies: But the helper T cell has to be activated to produce the IL-2 costimulator that activates the B cells and to stimulate the machrophages to secret the IL-1 that enhances B cell proliferation and differentiation into plasma cells…If the B cells do not differentiate they remain as memory B cells, ready to respond more rapidly and forcefully at the antigen. B cells can respond to unprocessed antigen dissolved in lymph or interstitial fluid and are able to perform immune adherence called opsonization, by coating the microbes in antibodies (immunoglobulin), but the helper T cells have to be activated by the IL-1 to activate IL-2 and more IL-1 to costimulated B cell proliferation and differentiation into plasma cells.

  AIDS:
  IS THE DISRUPTION THAT ALLOWS THE AIDS VIRUS TO GET A TOE HOLD THE EXTENDED LONG TERM REACTION OF THE 2ND STAGE STRESS RESPONSE TO THE CELL STARVATION, BROUGHT ON BY THE OXALIC AND PHYTIC ACIDS BLOCKING THE NUTRITIONAL DELIVERY SYSTEM?
  TRANSMISSION DISRUPTION: The initial disruption that would allow the easier transmission of the AIDS virus, would be the disruption in the storage of glycogen creating an insufficient supply. This disruption is created when the low ATP trigger kicks in and stops the storage of glycogen. Glycogen is the substance that the vagina needs to maintain a large storage of in order to produce the mucosa. In the mucosa upon decomposition glycogen produces organic acids that create a low pH environment that serves to retard microbial and bacterial growth.
  T4 CELL DISRUPTION: As the stress continues from the nutrient depletion, the body goes into the General adaptation syndrome in the long-term resistance reaction 2nd stage stress response. As the controlled ranges are reset the Cortisol secretion becomes excessive (discussed in the Stress response). When homeostasis cannot be achieved due to the two acids then the negative feedback system that keeps the immune response in check is disrupted. The immune system can not achieve its goal so it cannot be switched-off. Initially the IL-1 stimulates a powerful immune response to the stressors. IL-1 stimulates secretion of ACTH which stimulates production of Cortisol. And the Cortisol suppresses further production of IL-1… Thus the IL-1 becomes deficient. IL-1 must be present to costimulate the CD4 displaying helper T cells, without this stimulation the T cells cannot be activated an remain in a state of inactivity called anergy. In a state of anergy the T4 cells does not proliferate and differentiate cloning itself to form more highly specialized cells. Since the macrophages are inhibited from secreting IL-1, the T4 cells cannot be costimulated to secret cytokines such as IL-2, gamma-interferon, IL-4, and transforming growth factor beta (TGF-B)…IL-2 is needed for all immune responses and it is the prime trigger for T cell proliferation .It also serves as a costimulator of resting helper Tor catatonic T cells, and it enhances activation and proliferation of T cells, B cells, and natural killer cells. IL-2 serves as a Postive feedback system .IL-2 acts in a paracrine {cure all} manner by binding to neighboring Th, Tc or B cells and serves as a costimulator to activate them when they bind to an antigen.
  This disruption continues on much farther but it makes my point, on how the HIV can gain entry and cancers and toxins etc and seemingly the immune system is not activated are in major disarray. Well, it seems to me that it is! Because the body is in the 2nd stage long-term stress response and so the normal immune functions are inhibited. The deficient nutrients activate the stress response causing excessive cortisol which inhibits IL-1, and when the IL-1 is inhibited it cannot co stimulate the helper T cells to stimulate the cytokines, and the cytokines cannot stimulate the activity of monocytes, neutrophil and macrophages , IL-2, etc.
  AIDS DISRUPTIONS:
  Aids lowers the victim’s immunity. CD4 molecules on the T4 cells allow the HIV entry. Slowly the T4 cell population is destroyed , as the cells become infected and die. The result is a progressive collapse of the immune system. The cytokines, monocytes, neutrophils, macrophages and non-specific defense mechanisms are depressed. ..
  More Immune Disruptions:

  CANCER:

  IS CANCER SIMPLY THE CELLS’ RESPONSE TO THEIR CELLULAR METABOLISM BEING ROBBED, AND THE CELLS PERCEIVING THIS AS A VIRUS HAVING TAKEN OVER..
  A virus destroys a cell by taking over its cellular metabolism mechanism. So when the cell becomes so deficient that it can no longer perform its normal functions, it perceives a virus has infected it and so to protect the surrounding cells, it releases interferon which activates the inflammatory response. It also triggers a metabolism shift that inhibits the production of iron, zinc and other nutrients. It also activates increased synthesizes of proteins by the other cells to disrupt the atmosphere in which the virus would thrive. The increased activation of protein synthesize , would seem to me, to be over-ridding the instructions encoded on the surrounding cells’ DNA. Alteration of the DNA code means the cell has become damaged, and at this point cancerous changes are liable to occur. So the cells must go through cell death to make way for new cells and remove the damaged ones. The clotting factors that are suppose to trap released germs in these destructive processes, is disrupted by the deficient calcium, which plays a major role in the clotting process. So germs are not contained for the white blood cells to remove. This battle of trying to capture and destroy the escaping germs and taking care of all the damaged and dying cells takes a considerable toll on the white blood cells (neutrophil). In an excessive vigorous prolonged battle that is actively going on , the white blood cells can begin to spill their garbage disposing enzymes (lysosomal), into the surrounding areas. These garbage disposals (lysosomes) are already weakened by the lack of sufficient oxygen created by the declining iron, which causes them to become fragile and rupture and burst. The abnormal release of these enzymes does not only destroy the white blood cells, and the dying cells but also surrounding cells . This process can lead to pus and abscesses because the inflammatory responses that functions to remove this debris are inhibited by the excessive cortisol being released in the 2nd stage stress response, which has been activated by disruption in the nutritional delivery pathway. The prolonged battle can cause normal human tissues to become cancerous. I feel , the greater amount of the nutritional deficiency , would translate into a greater number of white blood cells being released into the blood , which is called leukocytosis. These disruptions in my opinion could be contributing to the development of cancer and leukemia… Then add on the disruption in the immune response listed under AIDS and it seems to me this has created the breeding grounds for cancer…
  Immunological surveillance disruption: The IL-1 stress related disruption in the activation of the cytotoxic T cells and macrophages and natural killer cells would open the chances up for a person to contract virus related cancers…Removal of the hindrance the original stressors the acid blockage, that leads to the stress response would allow the IL-2 to return to the activation process of the cytotoxic T cells and nautral killer cell causing them to return to the lymphokine-activated killer (LAK) cells naturally and without tumor immunotherapy or cytokine therapy, or antibody therapy, it would seem…

  NERVE AND BRAIN DISEASES:

  DISEASES OF A MALFUNCTIONING NERVE SYSTEM: COULD A COMBINATION OF INHIBITED CALCIUM IONS, OXYGEN DEF. LYSOSOMES, AND IRON DEFICIENCY IN THE CELLULAR METABOLISM, AND THE IRON DEF. RED NUCLEUI, BE THE DISRUPTIONS IN THE PERIPHAL NERVOUS SYSTEM THAT IS CREATING THE SYMPTOMS IN MYASTHENIA GRAVIS, PARKINSONS, ALZHEIMER’S, MS and THE HIV BREACH OF THE BLOOD BRAIN BARRIER ?
  If calcium ions are deficient then the chemical synapses are disrupted because there would be insufficient Ca2+ to increase and trigger the mechanism that causes the discharge of the neurotransmitters. The availability of neurotransmitters is a problem in Myasthenia Gravis, Parkinson’s, and Alzheimer’s to name a few … And calcium ions would be deficient with the excessive consumption of oxalic and phytic acids….So it looks to me like the deficient Ca2+ could be the cause of the deficiency in neurotransmitters transmission..
  Is the LYSOSOME DISRUPTION also causing the symptoms manifested in PARKINSON‘S, ALZHEIMER‘S, HIV BREACHING, MULTIPLE SCLEROSIS, AND STEM CELL DESTRUCTION?:
  When the lysosomes (garbage disposals) become oxygen deficient they become fragile rupture and burst. When they rupture in the brain they release nerve cell (neurons, neuroglia) destroying enzymes. The destroying enzymes can lead to the destruction of: the stem cells/ and cells that form the blood brain barrier / that form the supporting network around neurons / that produce the myelin sheath / that generate the dopamine / that maintain the proper balance of K+ which is responsible for the generation of nerve impulses / that participate in the metabolism of neurotransmitters / that participate in brain development / that provides the link between neurons and blood vessels / that clean up cellular debris in the Central Nervous System (CNS) / that line the ventricles of the brain and the central canal of the spinal cord / that form the cerebrospinal fluid (CSF) and assist in its circulation./ and that support neurons in the collections of neuronal cell bodies in the peripheral nervous system ..Translated the lack of oxygen in the lysosomes release enzymes that destroy Oligodendrocytes, astrocytes, microglia, ependymal cells, neurolemmocytes (schwann cells), satellite cells (stem cells)…
  Symptoms:
  PARKINSON‘S: In Parkinson’s the dopamine producing neurons degenerate, which looks like a symptom created by the oxygen deficient garbage disposals . And then add this to deficient iron disrupting the cluster of cell bodies in the midbrain called the “Red Nucleus” which plays a major role in coordination of muscular movements. Why couldn’t the nutritional disruption be playing a major role in diseases such as Parkinson’s?
  HIV BREACHING THE BLOOD BRAIN BARRIER : One disruption taking place that allows this abnormality , is when the oxygen deficient garbage disposals release the destructive enzymes that destroy the nerve cells that form the blood brain barrier, thus disrupting the barriers proper functions. But another pathway is when the excessive glucose (sugar) concentration causes the endothelial cells to shrink and open up gaps at junctures that normally would be closed, when they gape open they allow abnormal substances to pass.
  ALZHEIMERS: In Alzheimer’s the networking in the brain becomes tangled, large amount of neurons or
  destroyed and abnormal deposits of plaque. This all looks to me like the disruption in the garbage disposals are reeking havoc.
  MULTIPLE SCLEROSIS: A major symptom in MS is the destruction of the myelin sheath. This looks like the disruption in the garbage disposals, also.

  THYROID AND CHOLESTEROL DISRUPTIONS:
  Deficient iron inhibits the absorption of iodine, so the thyroid becomes deficient in its crucial nutrient iodine.. And the virus perception by the internal system of the nutrient starved cells activate the inflammatory process. As the inflammatory response is activated histamine is released which causes the capillaries to become permeable. This would cause excessive protein loss, including the Albumin. And a loss of albumin from the blood decreases blood’s ability to suspend particles in the blood (blood colloid osmotic pressure). The colloid is the gelatinous substance produced by the thyroid gland for storing hormones. So the process of storing thyroid hormones is disrupted. In the 2nd stage of the stress response the thyrotrophic releasing hormone (TRH) is released. TRH triggers the secretion of TSH (thyroid-stimulating hormone) which stimulates the secretion of T3 and T4 thyroid hormones. These thyroid hormones promote rapid uptake of glucose by the cells. If the storage of T3 and T4 is disrupted then the cells loss their ability to take up the glucose rapidly. The need to preserve the ATPs for the neurons become a fight or flight response and the ATP is the most important process that has to be preserved.
  The 2nd stage stress response releases the hGH which inhibit the cells from taking up glucose in order to preserve the glucose in the blood for the neurons. This action would be antagonistic to the thyroid hormones. So the internal hormones are caught in the a fight or flight responses and finally exhaustion the 3rd stage of the stress response takes control. And as the Thyroid hormones become depleted their functions such as stimulating the removal of cholesterol from the blood become diminished. Plus add this to the fact that the blood capillaries have become disrupted by the inflammatory histamine and osmotic disruptions, and excessive solutes as glucose causing the nephrotic syndrome resulting in high levels of cholesterol, phospholipids, and triglycerides in the blood. And the ground work is laid for the high cholesterol levels plaguing society, all at the hands of the excess of the two acids.

  THE DISRUPTION IN THE FEVER PROCESS:
  Fever would normally be present at an inflammation or infection to intensify the healing effects. But interleukin-1 is the hormone that regulates the immune response that activates fever, and interleukin-1 production is suppressed by the excessive amount of cortisol that is being released in the 2nd stage stress response that is triggered by the “cell starvation”. Metabolic dysfunctions and malnutrition created by the lack of oxygen in the cellular metabolism process, causes a reduced temperature. Plus the disruption in the thyroid , affects the fever process. All these disruptions lead me to feel that the fever process itself is trapped in a fight or flight response. A nurse once told me that most people did not have the 98.6 temperature. There was no reason for her to lie and I took her at her word, so what has happened that lowered peoples’ normal temperature, I wonder.. Could it be the lack of nutrition leading to a disrupted metabolism process?

  ACIDOSIS results in DISRUPTIONS IN ANTIBODIES, OXYGEN CARRYING ABILITY, CELL DIVISION, CHOLESTEROL, HORMONES, MUSCLE CONTRACTIONS, SPERM MOVEMENT, AND ENZYME CATALYSTS ACTIVITY.
  One of the major disruptions caused by acidosis is it inhibits the (functional proteins): antibodies [gamma globulins] / hormones / transport proteins: hemoglobin, cholesterol, iron transporters, and other substances / contractile proteins :which underlie movements in the body such as muscle contractions, cell division , and sperm propulsion / and catalysts enzymes which are essential to virtually every biochemical reaction in the body and increase the rates of chemical reactions by at least a million fold. These functional proteins become unable to perform their physiological roles. Functional proteins depends on intramolecular bonds, particularly hydrogen bonds, to maintain their structure. And their function depends on specific arrangements of atoms called active sites. These active sites allow them to interact chemically with other molecules. Hydrogen bonds are fragile and easily disrupted by excessive acidity. A disruption in the intramolecular bonds allows the separation of the atoms and this destroys the active sites. And functional proteins such as antibodies and transport proteins are disrupted: Example, hemoglobin becomes totally unable to bind and transport oxygen when blood pH becomes to acidic.

  ULCERS:
  With the starvation in the cells the fight or flight response is activated this translates into the SYMPATHETIC NERVE PATHWAY being activated. And the activation of the sympathetic system inhibits the secretion by the Brunner’s gland which is the thick mucos secreting glands. This is what protects the mucosa from digestion by the acidic chyme and gastric juices. So why couldn’t this disruption be the beginning point of ulcers?

  SCLERODERMA:
  Collagen is an albumin type of protein . So if the inflammation reaction leads to cell permeability due the excess histamine, and this cell permeability allows Albumin to become deficient because it passes out of its normal place into the urine , why wouldn’t it have a disrupting effect on collagen balance?

  BIRTH DEFECTS:
  GLYCOGEN serves as nourishment for the early embryo…Glycogen availability is inhibited due to the fact that the oxalic and phytic acids block the metabolism of ATPs thus causing a deficiency in the storage of glycogen and so there would not be an ample supply of glycogen to nurture the embryo…./ The fetus and newborns naturally acquired passive immunity would be disrupted by the inhibited Immunological memory process, in the mother. The babies resistance stems mainly from the IgG antibodies.
  Immunological memory arises during proliferation and differentiation of antigen-stimulated B and T cells. The deficiency of the IL-1 caused by the stress activated cortisol would cause an incomplete primary response. Thus there would be a deficiency in the IgG antibodies from a secondary response, that afford the naturally acquired passive immunity protection.

  OBESITY:
  The cell starvation caused by these two acids will not allow the satiety “satisfied” center to be stimulated..
  So it just stands to reason people would be hungry all the time eating and getting obese.
  JUST TIDBITS:
  DEFICIENT IRON DISRUPTS THE CELLULAR METABOLISM CREATING MAJOR DISRUPTIONS:
  Excessive oxalic and phytic acids and excessive phosphates create excessive insoluble iron complexes. Combined this with the fact that the malfunctioning dying cells are releasing iron inhibitors and the result is a deficiency in usable iron. So as the availability of usable iron declines so does the availability of sufficient oxygen. When there is not sufficient oxygen in the cellular metabolism process then cell energy (ATP) cannot be produced.

  THE STRESS RESPONSE IN EXCESS LEADING TO THE IMMUNE RESPONSE DISRUPTION: COULD THIS BE THE AIDS SYMPTOMS and DIABETES?:
  The 2nd stage stress response called the “resistance reaction”, is a long-term reaction. And since homeostasis cannot be brought back to the body (without intervention) then the hormones released in this response would accumulate and become excessive. These hormones cause long-term secretion of cortisol and hGH. Excessive hGH causes diabetes. Excessive cortisol disrupts the negative feedback system that regulates the immune response.

  MY OPINION WHY THE OXALIC AND PHYTIC ACIDS BUILD- UP:
  The helper T cells aids in all immune responses and that is inhibited by the stress response. I feel the calcium in the insoluble calcium salts creates and inability for the immune system to view them as foreign substances so they are not being targeted for removal. Thus they are allowed to build up and create the malfunction in the nutritional pathway. And when the cells began to destroy themselves because they think they are infected with a virus, no virus is there, because the culprits (the insoluble calcium salts) do their dirty work from a distance..

  INSOLUBLE AND INHIBITED IRON, THE DISRUPTION THAT CAUSES THE CELLULAR METABOLISM MALFUNCTION AND OXYGEN DEFICIENCY .
  The metabolism shift caused by the starving cells that are dying, attempting to protect surrounding cells, along with excessive oxalic and phytic acids and excessive phosphates creates inhibited, and insoluble iron complexes, which leads to an iron deficiency. An iron deficiency leads to deficient oxygen in the cellular respiration electron transport chain, which disrupts the metabolism of ATPs and creates many major disruptions including excessive hydrogen which results in acidosis.. Also the deficient oxygen causes a cell garbage disposals (lysosomes) disruption. When the lysosomes are deficient in oxygen, they become fragile rupture and burst and release nerve cell destroying enzymes. Stem cells is one of the cells destroyed in this disruption.

  Hormonal disruption : Inhibited Pth leads to deficient activation of Vit. D, which leads to decreased synthesizes of the Calcitriol hormone creating a deficiency…aka 1,25-dihydroxycholecalciferol or 1,25-dihydroxy vitamin D3.
  Nutrient disruptions: Inhibited PTH would cause excessive phosphates, deficient Calcium, deficient Mg+, deficient activation of Vit. D leading to the deficiency in Calcitriol hormone. Reduced calcium causes elevated levels of phosphate.
  Excessive Aldosterone: leads to major ion disruptions: excessive water , excessive Na+, excessive Cl- because it follows Na+ passively , .deficient K+ and this disrupts the regulation of pH because
  Osmotic gradient disruption: disrupted with the disruption in the Na+ which is its regulator..
  Disruption in the Anions: Because the exchange of Cl- for HCO3- maintains the correct balance of anions in ECF and ICF.
  Imbalance in the HCI: Excessive Cl- and H+ disrupts the balance of hydrochloric acid..
  Disruption in pH regulation: deficient K+ and excessive H+ disrupt the H+ shift exchange.
  Neuromuscular and cardiac functions disrupted: when K+ is deficient.
  Resting membrane potential and repolarization phase of action potentials in muscles disrupted: by deficient K+.
  Fluid volume in cells disrupted: by deficient K+.
  Disruption in the electrochemical gradient: the ion disruption caused mainly by the excessive aldosterone but also by the def. calcium and excessive phosphate disrupts the anion, the negatively charge and the cations postively charge in the cells and the ECF..
  Disruption of the CSF and its functions such as protecting the brain and spinal cord from chemical and physical injury and its role in maintaining homeostasis : imbalances in the chemical composition
  Negative feed back systems activated: The Renin -angiotensin system in regulation of blood pressure and therefore glomerular filtration rate….the efferent arterioles constrict to increase glomerular blood , hydrostatic pressure, secretion of aldosterone causes retention of Na+, Cl-, and water to increase blood volume, the thirst center signals increased thirst when angiotensin II is increased, thus increased water intake leads to increased blood volume, and the increased ADH causes water retention to increase blood volume. The negative feedback regulation of glomerular filtration rate by the juxtaglomerular apparatus (JGA): the low blood pressure causes a decrease in the net filtration pressure and the glomerular filtration rate . The JGA decrease secretion of vasoconstrictor substances causing the afferent arteriole to dilate which increase blood flow through glomerulus.
  DISRUPTION IN THE PROCESS OF GENETIC RECOMBINATIONS, THAT DISRUPTS THE DIVERSTIY OF ANTIGEN RECEPTORS: The mini-genes are put together in different combinations as the lymphocytes are developing from the stem cells in red bone marrow and the thymus gland. This process is what gives the B and T cells their unique set of mini-genes that codes the transcripts and transulations for its unique antigen receptors. This process is disrupted by the deficient lysosomes that become fragile and rupture releasing stem cell destroying enzymes…(688 br)…

  The following letter was in response to an article on the internet. I never got it through to the researcher. I am just tossing it in, in case you might have some of the same questions. It was concerning MSG toxicity.

  I was informed of the kind of work you are doing and your work says you do not understand why the oligodendrocytes are being destroyed in MS and why our body is not removing toxins such as the MSG and something was causing a disruption in the calcium channels. I believe the information I have gathered explains that well.. The problem is the nutrients (beginning with calcium) are blocked from reaching the cellular metabolism process by excessive insoluble calcium salts in the interstitial fluid that blocks the nutrient delivery pathway to the cells. . There are two acids in excess that block this process. The disruption starts with the excessive insoluble calcium in the interstitial fluid but one of the branches that it leads to, is the disruption in the utilization of iron by the cells. This blockage of the utilization of iron causes the oxygen disruption in the lysosomes that is the answer to your puzzle of what is destroying oligodendrocytes…When the lysosomes become oxygen deficient they become fragile and rupture and burst and release enzymes that destroy the nerve cells (neurons, astrocytes, oligodendrocytes, microglia, ependymal cells, neurolemmocytes (schwann cells), and the satellite cells (stem cells). And I feel that is the cause of the myelin sheath disruption and the breaching the blood brain barrier disruption, that you are seeing This weakened state in the lysosomes would disable them from sufficiently removing toxins from the body. The following disruption in the ATP metabolism and an osmotic disruption causes the concentrated solute along with the histamine activation in the virus response, which makes the endothelial cells shrink and open up gaps that allow passage of substances that are suppose to be contained. And inability to create ATPs trigger the release of excessive human growth hormone in the 2nd stage of stress response..
  The branches of malfunctions that cause the disruption in the utlization of Iron by the cells:
  First, these acids disrupt the phosphate calcium balance by creating the insoluble calcium salts that saturate the interstitial fluid which inhibit the PTH. This disruption in the PTH creates a malfunction in the calcium phosphate negative feedback regulating system the “PTH/ Calcitonin” system. This creates excessive phosphates. Excessive phosphates and these two acids Oxalic and phytic acids create insoluble iron complexes.. So you have three substances creating insoluble Iron complexes, that the cells cannot utilize…
  Second , as the cells began to starve and die because they cannot receive enough nutrients to function they perceive that they have been infected by a virus because viruses take-over the cells metabolism process robbing the cells of nutrients.. When a cell perceive a virus-infection (deprived nutrition) , in order to protect the surrounding cells it activate the inflammation process by releasing interferon and activating nutritional immunity which inhibit the surrounding cells from absorbing iron and zinc and other nutrients in order to make the environment unfriendly to the virus, thus causing it to die.. So the greater the blockage of nutrients, the greater the cell starvation which means a greater amount of disruption in iron absorption by the other cells…
  As the utilization of iron is diminished then the oxygen becomes deficient creating a disruption in the cellular respiration electron transport chain. When oxygen becomes deficient the last cytochrome in the electron transport chain becomes stuck with hydrogen blocking the electron transport system all the way back to the NAD stage and no further ATPs are produced and creates excessive hydrogen. Excessive hydrogen ions means high acidity. The intramolecular hydrogen bonds are fragile and are easily disrupted by excessive acidity. This disrupts the active sites in the functional proteins and they cannot perform their physiological roles. So hemoglobin for example, becomes totally unable to bind and transport oxygen when blood is to acidic because the active sites have become destroyed…

  munchiej@yahoo.com