Retrovirus Integration Site Selection
The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the virus and the host cell. The analysis of retroviral integration site distribution was facilitated by the availability of the human genome sequence, revealing the non-random feature of integration site selection and identifying different favored and disfavored genomic locations for individual retroviruses. This new review summarizes the current knowledge about retrovirus differences in their integration site preferences as well as the mechanisms involved in this process.
Retroviral Integration Site Selection. Viruses 2010, 2(1) 111-130. doi:10.3390/v2010111
Related:
- Current and Novel Inhibitors of HIV Protease
- Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases
- HIV-1 Protease: Structural Perspectives on Drug Resistance
- Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
- HIV-1 Integrase-DNA Recognition Mechanisms
- Revisiting Plus-Strand DNA Synthesis in Retroviruses and Long Terminal Repeat Retrotransposons
Tags: Biology, HIV/AIDS, Medicine, Microbiology, retrovirus, Science, Virology, virus
