Stabilization of vaccines and antibiotics in silk and eliminating the cold chain
This article was well covered by the press and bloggers when it appeared last week, but as it is potentially the most exciting thing about vaccination I have heard in years, I have no hesitation in suggesting you should read it:
Stabilization of vaccines and antibiotics in silk and eliminating the cold chain. PNAS USA 09 July 2012, doi: 10.1073/pnas.1206210109
Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent “cold chain” to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate self-standing silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60°C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.