Systemic Lupus Erythematosus (SLE)

Patients with SLE have antibodies against a wide range of autoantigens. In the picture below, a slice of rat liver was incubated with serum from an SLE patient, then with fluorescent anti-human IgG. Fluorescence of the nuclei in the tissue show the presence of anti-nuclear antibodies (ANA). This is typical of SLE, but also occurs in a range of other autoimmune and connective tissue diseases.

In SLE patients, circulating immune complexes of DNA-anti DNA may settle at various sites, e.g. the glomerular basement membrane, causing kidney damage, as in this biopsy specimen:

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